Lack of efficacy of phosphatidylcholine in ataxias

S Sorbi; S Piacentini; P Marini; G De Scisciolo; A Amantini; L Amaducci

doi:10.1212/wnl.38.4.649

Lack of efficacy of phosphatidylcholine in ataxias

Neurology. 1988 Apr;38(4):649-50. doi: 10.1212/wnl.38.4.649.

Authors

S Sorbi¹, S Piacentini, P Marini, G De Scisciolo, A Amantini, L Amaducci

Affiliation

¹ Department of Neurology, University of Florence, Italy.

PMID: 3352929
DOI: 10.1212/wnl.38.4.649

Abstract

We gave phosphatidylcholine orally at a daily dosage of 9 grams for 4 years to 20 subjects with Friedreich's ataxia (FA) and 24 with olivopontocerebellar atrophy (OPCA). There was no clinical improvement during the follow-up compared with 12 ataxic patients (six FA and six OPCA) who did not receive any treatment. A 6-month trial at a double dose did not have any significant effect. This study indicates that phosphatidylcholine does not change the natural course of ataxias.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Ataxia / drug therapy*
Female
Humans
Male
Olivopontocerebellar Atrophies / drug therapy
Phosphatidylcholines / therapeutic use*

Substances

Phosphatidylcholines