Challenges of using protein antibiotics for pathogen control

Pest Manag Sci. 2021 Sep;77(9):3836-3840. doi: 10.1002/ps.6312. Epub 2021 Feb 26.

Abstract

Bacterial phytopathogens represent a significant threat to many economically important crops. Current control measures often inflict harm on the environment and may ultimately impact on human health through the spread of antibiotic resistance. Antimicrobial proteins such as bacteriocins have been suggested as the next generation of disease control agents since they are able to specifically target the pathogen of interest with minimal impact on the wider microbial community and environment. However, substantial gaps in knowledge with regards to the efficacy and application of bacteriocins to combat phytopathogenic bacteria remain. Here we highlight the immediate challenges the community must address to ensure maximum exploitation of antimicrobial proteins in the field. © 2021 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Keywords: Pectobacterium; Pseudomonas syringae; bacterial phytopathogens; bacteriocins.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents* / pharmacology
  • Bacteria
  • Bacteriocins* / pharmacology
  • Crops, Agricultural
  • Humans

Substances

  • Anti-Bacterial Agents
  • Bacteriocins