How Could Antibiotics, Probiotics, and Corticoids Modify Microbiota and Its Influence in Cancer Immune Checkpoint Inhibitors: A Review

Mara Cruellas; Alfonso Yubero; María Zapata; Eva M Galvez; Marta Gascón; Dolores Isla; Rodrigo Lastra; Luis Martínez-Lostao; Maitane Ocariz; Julián Pardo; Ariel Ramírez; Andrea Sesma; Irene Torres-Ramón; José Ramón Paño

doi:10.1128/IAI.00665-20

How Could Antibiotics, Probiotics, and Corticoids Modify Microbiota and Its Influence in Cancer Immune Checkpoint Inhibitors: A Review

Infect Immun. 2021 Aug 16;89(9):e0066520. doi: 10.1128/IAI.00665-20. Epub 2021 Aug 16.

Authors

Mara Cruellas^{1

2}, Alfonso Yubero^{1

2}, María Zapata^{1

2}, Eva M Galvez³, Marta Gascón^{1

2}, Dolores Isla^{1

2}, Rodrigo Lastra^{1

2}, Luis Martínez-Lostao^{2

4

5

6

7}, Maitane Ocariz^{1

2}, Julián Pardo^{2

8

9

10}, Ariel Ramírez¹¹, Andrea Sesma^{1

2}, Irene Torres-Ramón^{1

2}, José Ramón Paño^{2

12}

Affiliations

¹ Medical Oncology Department, University Hospital Lozano Blesa, Zaragoza, Spain.
² Aragon Health Research Institute (IIS Aragón), Zaragoza, Spain.
³ Carbochemical Institute (ICB-CSIC), Zaragoza, Spain.
⁴ Immunology Department, University Hospital Lozano Blesa, Zaragoza, Spain.
⁵ Department of Microbiology, Pediatrics, Radiology and Public Health, University of Zaragoza, Zaragoza, Spain.
⁶ Aragon Nanoscience institute, Zaragoza, Spain.
⁷ Aragon Materials Science Institute, Zaragoza, Spain.
⁸ ARAID Foundation (IIS Aragón), Zaragoza, Spain.
⁹ Microbiology, Preventive Medicine and Public Health Department, Medicine, University of Zaragoza, Zaragoza, Spain.
¹⁰ Biomedical Research Center in Bioengineering, Biomaterials and Nanomedicine Network (CIBER-BBN), Madrid, Spain.
¹¹ Nanotoxicology and Immunotoxicology Unit (IIS Aragón), Zaragoza, Spain.
¹² Infectious Disease Department, University Hospital Lozano Blesa, Zaragoza, Spain.

Abstract

Immunotherapy has become a new paradigm in oncology, improving outcomes for several types of cancer. However, there are some aspects about its management that remain uncertain. One of the key points that needs better understanding is the interaction between immunotherapy and gut microbiome and how modulation of the microbiome might modify the efficacy of immunotherapy. Consequently, the negative impact of systemic antibiotics and corticosteroids on the efficacy of immunotherapy needs to be clarified.

Keywords: antibiotics; cancer immunotherapy; corticosteroids; gut microbiota; immune checkpoint inhibitors; immunotherapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adrenal Cortex Hormones / pharmacology*
Adrenal Cortex Hormones / therapeutic use
Animals
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Host Microbial Interactions* / drug effects
Host Microbial Interactions* / immunology
Humans
Immune Checkpoint Inhibitors / pharmacology
Immune Checkpoint Inhibitors / therapeutic use*
Immunomodulation / drug effects
Microbial Interactions / drug effects
Microbial Interactions / immunology
Microbiota* / drug effects
Neoplasms / drug therapy*
Neoplasms / etiology
Probiotics*
Treatment Outcome

Substances

Adrenal Cortex Hormones
Anti-Bacterial Agents
Immune Checkpoint Inhibitors