Magnetic reduced graphene oxide as a nano-vehicle for loading and delivery of curcumin

Abstract

Magnetic nanoparticles have been widely used in the field of nanomedicine as drug delivery vehicles for targeted imaging-guided and controlled drug uptake and release actions. In this work, the loading of curcumin on Fe₃O₄/rGO nanocomposites and their interaction mechanism were investigated by multispectral methods including resonance light scattering (RLS), atomic force microscopy (AFM), circular dichroism (CD) and Fourier transform infrared (FT-IR). Results revealed that the drug loading was a complex process which is not governed by a simple adsorption. The interactions of vitro human serum albumin (HSA) with free curcumin and/or curcumin-Fe₃O₄/rGO complex have been studied. Outcomes from the fluorescence quenching showed that the binding constant of curcumin to HSA increased significantly in the presence of Fe₃O₄/rGO, confirming the enhanced effect of Fe₃O₄/rGO besides its low toxicity towards HSA. Findings from this work verified that Fe₃O₄/rGO nanocomposite has a promising potential as a good drug loading carrier that can be used and broad range of therapies.

Keywords: Curcumin; Drug carriers; Fe(3)O(4)/rGO; Human serum albumin.