Melanin is a dark brown to black biomacromolecule with biologically active multifunctional properties that do not have a precise chemical structure, but its structure mainly depends on the polymerization conditions during the synthesis process. Natural melanin can be isolated from various animal, plant, and microbial sources, while synthetic melanin-like compounds can be synthesized by simple polymerization of dopamine. Melanin is widely used in various areas due to its functional properties such as photosensitivity, light barrier property, free radical scavenging ability, antioxidant activity, etc. It also has an excellent ability to act as a reducing agent and capping agent to synthesize various metal nanoparticles. Melanin nanoparticles (MNP) or melanin-like nanoparticles (MLNP) have the unique potential to act as functional materials to improve nanocomposite films' physical and functional properties. Various food packaging and biomedical applications have been made alone or by mixing melanin or MLNP. In this review, the general aspects of melanin that highlight biological activity, along with a description of MNP and the use as nanofillers in packaging films as well as reducing and capping agents and biomedical applications, were comprehensively reviewed.
Keywords: Biomedical; functional properties; melanin; nano-melanin; nanofillers; packaging application.