Low-Power Near-Infrared-Responsive Upconversion Nanovectors

Jun Xiang; Shenglin Zhou; Jianxun Lin; Jiating Wen; Yutong Xie; Bin Yan; Qiang Yan; Yue Zhao; Feng Shi; Haojun Fan

doi:10.1021/acsami.0c21115

Low-Power Near-Infrared-Responsive Upconversion Nanovectors

ACS Appl Mater Interfaces. 2021 Feb 17;13(6):7094-7101. doi: 10.1021/acsami.0c21115. Epub 2021 Feb 1.

Authors

Jun Xiang¹, Shenglin Zhou¹, Jianxun Lin¹, Jiating Wen¹, Yutong Xie¹, Bin Yan¹, Qiang Yan², Yue Zhao³, Feng Shi⁴, Haojun Fan¹

Affiliations

¹ College of Biomass Science and Engineering, Key Laboratory of Leather Chemistry and Engineering of Ministry of Education, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, P.R. China.
² State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, P.R. China.
³ Département de Chimie, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.
⁴ School of Materials Science and Engineering, Shaanxi Normal University, Xi'an 710119, P.R. China.

PMID: 33522229
DOI: 10.1021/acsami.0c21115

Abstract

Activating upconversion nanoparticle-based photoresponsive nanovectors (UCPNVs) by upconversion visible light at low-power near-infrared (NIR) excitation can realize deeper biotissue stimulation with a minimized overheating effect and photodamage. Here, we demonstrate a facile strategy to construct new surface-decorated UCPNVs based on Passerini three-component reaction (P-3CR) in highly convenient and effective manners. Such UCPNVs materials have a tailored deprotecting wavelength that overlaps upconversion blue light. By using 3-perylenecarboxaldehyde, Tm³⁺/Yb³⁺ ion-doped UCNP-containing isocyanides, and antitumor agent chlorambucil as the three components, the resulting monodisperse UCPNV exhibits an efficient release of caged chlorambucil under a very low 976 nm power. This approach expands the synthetic toolbox to enable quick development of UCPNVs for UCNP-assisted low-power NIR photochemistry.

Keywords: Passerini three-component reaction; low-power NIR excitation; monodisperse; perylene-derived photocage; upconversion nanoparticle-based photoresponsive nanovectors.