LncRNA-Encoded Peptide: Functions and Predicting Methods

Jiani Xing; Haizhou Liu; Wei Jiang; Lihong Wang

doi:10.3389/fonc.2020.622294

LncRNA-Encoded Peptide: Functions and Predicting Methods

Front Oncol. 2021 Jan 14:10:622294. doi: 10.3389/fonc.2020.622294. eCollection 2020.

Authors

Jiani Xing¹, Haizhou Liu², Wei Jiang², Lihong Wang^{1

3}

Affiliations

¹ Department of Pathophysiology, Medical College of Southeast University, Nanjing, China.
² Department of Biomedical Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China.
³ Jiangsu Provincial Key Laboratory of Critical Care Medicine, Nanjing, China.

Abstract

Long non-coding RNA (lncRNA) was originally defined as the representative of the non-coding RNAs and unable to encode. However, recent reports suggest that some lncRNAs actually contain open reading frames that encode peptides. These coding products play important roles in the pathogenesis of many diseases. Here, we summarize the regulatory pathways of mammalian lncRNA-encoded peptides in influencing muscle function, mRNA stability, gene expression, and so on. We also address the promoting and inhibiting functions of the peptides in different cancers and other diseases. Then we introduce the computational predicting methods and data resources to predict the coding ability of lncRNA. The intention of this review is to provide references for further coding research and contribute to reveal the potential prospects for targeted tumor therapy.

Keywords: Ribo-seq; cancer; long non-coding RNA; peptide; translation.

Publication types

Review