Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds

Takashi Yamazaki; Yoh Nakajima; Minato Iida; Tomoko Kawasaki-Takasuka

doi:10.3762/bjoc.17.14

Facile preparation and conversion of 4,4,4-trifluorobut-2-yn-1-ones to aromatic and heteroaromatic compounds

Beilstein J Org Chem. 2021 Jan 15:17:132-138. doi: 10.3762/bjoc.17.14. eCollection 2021.

Authors

Takashi Yamazaki¹, Yoh Nakajima¹, Minato Iida¹, Tomoko Kawasaki-Takasuka¹

Affiliation

¹ Division of Applied Chemistry, Institute of Engineering, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei 184-8588, Japan.

Abstract

The concise preparation of 4,4,4-trifluorobut-2-yn-1-ones by the oxidation of the readily accessible corresponding propargylic alcohols as well as their utilization as Michael acceptors for the construction of aromatic and heteroaromatic compounds are reported.

Keywords: CF3-containing propargylic alcohols; CF3-containing ynones; oxidation; pyrimidines; salicylate derivatives.