Working Memory Alterations Plays an Essential Role in Developing Global Neuropsychological Impairment in Duchenne Muscular Dystrophy

Rahul Tyagi; Harshita Arvind; Manoj Goyal; Akshay Anand; Manju Mohanty

doi:10.3389/fpsyg.2020.613242

Working Memory Alterations Plays an Essential Role in Developing Global Neuropsychological Impairment in Duchenne Muscular Dystrophy

Front Psychol. 2021 Jan 15:11:613242. doi: 10.3389/fpsyg.2020.613242. eCollection 2020.

Authors

Rahul Tyagi¹, Harshita Arvind¹, Manoj Goyal², Akshay Anand¹, Manju Mohanty³

Affiliations

¹ Neuroscience Research Lab, Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
² Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
³ Department of Neurosurgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Abstract

Background: Neuropsychological profile of Indian Duchenne muscular dystrophy (DMD) subjects remains unidentified and needs to be evaluated.

Methods: A total of 69 DMD and 66 controls were subjected to detailed intelligence and neuropsychological assessment. The factor indexes were derived from various components of Malin's Intelligence Scale for Indian Children (MISIC) and Rey Auditory Verbal Learning Test (RAVLT).

Results: Poor verbal and visual memory profiles were demonstrated by DMDs, which include RAVLT-immediate recall (IR) (p = 0.042), RAVLT-delayed recall (DR) (p = 0.009), Rey-Osterrieth complex figure test (RCFT)-IR (p = 0.001), and RCFT-DR (p = 0.001). RAVLT-memory efficiency index demonstrated poor verbal memory efficiency (p = 0.008). Significant differences in the functioning of working memory axis [RAVLT T1 (p = 0.015), recency T1 (p = 0.004), Digit Span Backward (p = 0.103)] were observed along with reduced performance in visuomotor coordination, visuospatial, and visual recognition abilities. Block designing efficiency index and attention fraction showed a normal performance in DMD kids.

Conclusion: Working memory deficits were found to be the crucial element of cognitive functioning in DMD cases. Working memory interventions may be beneficial to improve the neuropsychological profile in DMD.

Keywords: DMD; Duchenne muscular dystrophy; intelligence; neuropsychology; working memory.