Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products

Liang Ma; Wenjun Zhang; Zhiwen Liu; Yanbing Huang; Qingbo Zhang; Xinpeng Tian; Changsheng Zhang; Yiguang Zhu

doi:10.1016/j.margen.2020.100803

Complete genome sequence of Streptomyces sp. SCSIO 03032 isolated from Indian Ocean sediment, producing diverse bioactive natural products

Mar Genomics. 2021 Feb:55:100803. doi: 10.1016/j.margen.2020.100803. Epub 2020 Jul 9.

Authors

Liang Ma¹, Wenjun Zhang¹, Zhiwen Liu¹, Yanbing Huang², Qingbo Zhang¹, Xinpeng Tian¹, Changsheng Zhang¹, Yiguang Zhu³

Affiliations

¹ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No. 1119, Haibin Road, Nansha District, Guangzhou 511458, China.
² CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Guangxi Key Laboratory of Marine Natural Products and Combinatorial Biosynthesis Chemistry, Beibu Gulf Marine Research Center, Guangxi Academy of Sciences, Nanning 530007, China.
³ CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Innovation Academy of South China Sea Ecology and Environmental Engineering, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), No. 1119, Haibin Road, Nansha District, Guangzhou 511458, China. Electronic address: ygzhu@scsio.ac.cn.

PMID: 33517980
DOI: 10.1016/j.margen.2020.100803

Abstract

Streptomyces sp. SCSIO 03032, isolated from a deep-sea sediment sample (-3412 m) from the Indian Ocean, produces several classes of bioactive compounds including α-pyridone antibiotics (piericidins), polycyclic macrolactams (heronamides) and bisindole alkaloids (spiroindimicins, indimicins and lynamicins). Here we report the complete genome sequence of Streptomyces sp. SCSIO 03032, which consists of a 6,287,975 bp linear chromosome. The genome analysis reveals the presence of 29 putative biosynthetic gene clusters for secondary metabolites, including those for piericidins, heronamides and spiroindimicins/indimicins/lynamicins. The genome sequence suggests that Streptomyces sp. SCSIO 03032 could be a producer for novel bioactive natural products with potential applications in drug discovery.

Keywords: Biosynthetic gene cluster; Bisindole alkaloids; Deep-sea; Heronamides; Piericidins; Secondary metabolites.

MeSH terms

Biological Products / chemistry*
Genome, Bacterial*
Geologic Sediments / microbiology*
Indian Ocean
Streptomyces / genetics*
Whole Genome Sequencing

Substances

Biological Products