Towards Evidence-based Control of Opisthorchis viverrini

Thomas Crellen; Paiboon Sithithaworn; Opal Pitaksakulrat; Narong Khuntikeo; Graham F Medley; T Déirdre Hollingsworth

doi:10.1016/j.pt.2020.12.007

Towards Evidence-based Control of Opisthorchis viverrini

Trends Parasitol. 2021 May;37(5):370-380. doi: 10.1016/j.pt.2020.12.007. Epub 2021 Jan 28.

Authors

Thomas Crellen¹, Paiboon Sithithaworn², Opal Pitaksakulrat³, Narong Khuntikeo⁴, Graham F Medley⁵, T Déirdre Hollingsworth⁶

Affiliations

¹ Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK. Electronic address: thomas.crellen@bdi.ox.ac.uk.
² Department of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand; Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand.
³ Department of Parasitology, Khon Kaen University, Khon Kaen 40002, Thailand.
⁴ Cholangiocarcinoma Research Institute, Khon Kaen University, Khon Kaen 40002, Thailand; Department of Surgery, Khon Kaen University, Khon Kaen 40002, Thailand.
⁵ Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15-17 Tavistock Place, London, WC1H 9SH, UK.
⁶ Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, OX3 7LF, UK.

PMID: 33516657
DOI: 10.1016/j.pt.2020.12.007

Abstract

Transmission of the carcinogenic liver fluke Opisthorchis viverrini is ongoing across Southeast Asia. Endemic countries within the region are in different stages of achieving control. However, evidence on which interventions are the most effective for reducing parasite transmission, and the resulting liver cancer, is currently lacking. Quantitative modelling can be used to evaluate different control measures against O. viverrini and assist the design of clinical trials. In this article we evaluate the epidemiological parameters that underpin models of O. viverrini and the data necessary for their estimation, with the aim of developing evidence-based strategies for parasite control at a national or regional level.

Keywords: cholangiocarcinoma; food borne trematodes; liver fluke; mass drug administration; statistical modelling.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Evidence-Based Practice* / trends
Humans
Opisthorchiasis* / epidemiology
Opisthorchiasis* / prevention & control
Opisthorchis