Aidi Injection as Adjuvant Drug Combined with Chemotherapy in Treatment of Breast Cancer: A Systematic Meta-Analysis

Chenhao Wu; Yongjun Qi; Juan Zhou; Chen Yao; Min Miao; Chen Cheng

doi:10.1155/2021/8832913

Aidi Injection as Adjuvant Drug Combined with Chemotherapy in Treatment of Breast Cancer: A Systematic Meta-Analysis

Evid Based Complement Alternat Med. 2021 Jan 8:2021:8832913. doi: 10.1155/2021/8832913. eCollection 2021.

Authors

Chenhao Wu¹, Yongjun Qi², Juan Zhou², Chen Yao², Min Miao², Chen Cheng²

Affiliations

¹ Breast Surgery Department, Hainan Women and Children's Medical Center, No. 75 Longkun Nan Road, Hai Kou, Hainan Province, China.
² Obstetrics and Gynecology Department, Jiangdu People's Hospital of Yangzhou, No. 9 Dongfang Hong Road, Jiangdu District, Yangzhou, Jiangsu Province, China.

Abstract

Objective: To compare the efficacy and safety of combination of Aidi injection and chemotherapy and chemotherapy alone in treatment of breast cancer.

Methods: The related control and randomized studies till August 1^st, 2020, were retrieved in the database including PubMed, Embase, Cochrane Library, CNKI, CBM, Wang-Fang, and VIP. Primary outcomes were response rate (RR) and performance status (KPS) improvement rate; secondary outcomes were rate of adverse drug reactions (ADR) including myelosuppression, digestive tract reaction, liver dysfunction, and cardiac toxicity. Review Manager 5.3 was used in the present analysis.

Results: In total, 20 studies (18 articles) were included in the present analysis. RR (OR 1.76 (1.32, 2.35); p=0.0001) and KPS improvement rate (OR: 2.68 (1.34, 6.46); p=0.007) in Aidi injection plus chemotherapy group were significantly higher than those of chemotherapy alone group. Addition of Aidi injection significantly reduced the rate of myelosuppression, digestive tract reaction, leukocyte decrease, II-IV cardiac function abnormality, atrial dysrhythmia, ventricular arrhythmia, ST segment T wave inversion, and abnormal ECG (all p < 0.05).

Conclusion: Aidi injection could increase the efficacy of chemotherapy, could reduce myelosuppression, digestive tract reaction, and cardiac toxicity induced by chemotherapy, and did not lead to additional toxicity and side effect. Therefore, it is an anticancer drug with good efficacy and low toxicity, worth further popularization.

Publication types

Review