Association between laboratory parameters and CT severity in patients infected with Covid-19: A retrospective, observational study

Am J Emerg Med. 2021 Apr:42:110-114. doi: 10.1016/j.ajem.2021.01.040. Epub 2021 Jan 20.

Abstract

Introduction: Patients diagnosed with COVID-19 have presented to emergency departments (EDs) worldwide with a wide range of symptoms. In this study we reported the clinical, laboratory and radiological features of the cases diagnosed with COVID-19.

Methods: This is a single-center, retrospective, descriptive, and observational study. The patients who have admitted to ED between March 11 and May 31, 2020 and diagnosed COVID-19 infection.

Results: 130 (73 male and 57 female) patients with COVID-19 polymerase chain reaction (PCR) positive test were included in the study. The average age of the study group was calculated as 52.63 ± 17.95 year. While 15.4% of the patients were asymptomatic, the most common symptom was identified as cough (46.2%), followed by dyspnea (23.1%), fever (17.7%). The computed tomography (CT) severity scores proved significantly higher in the patients with hypertension and coronary artery disease (CAD) than in those without these diseases (p = 0.010 and p = 0.042, respectively). The moderate positive correlation between serum ferritin level and CT severity score is another finding worth noting (rho = 0.530 and p = 0.0001). In a similar vein, the high level of D-dimer in the CT-positive group and its positive moderate correlation with CT severity (rho = 0.375 and p = 0.0001).

Conclusion: In our study, serum ferritin and D-dimer levels were observed to be high in the CT-positive group and have moderate positive correlation with CT severity. We thus argue that D-dimer and ferritin levels measured at the time of admission to the ED can be taken into consideration to predict radiological severity.

Keywords: COVID-19; CT severity; D-dimer; Ferritin.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Aged
  • COVID-19 / blood*
  • COVID-19 / complications
  • COVID-19 / diagnostic imaging*
  • COVID-19 Nucleic Acid Testing
  • Female
  • Ferritins / blood
  • Fibrin Fibrinogen Degradation Products / metabolism
  • Humans
  • Lung / diagnostic imaging*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Reverse Transcriptase Polymerase Chain Reaction
  • SARS-CoV-2 / isolation & purification
  • Severity of Illness Index
  • Symptom Assessment
  • Tomography, X-Ray Computed
  • Turkey

Substances

  • Fibrin Fibrinogen Degradation Products
  • fibrin fragment D
  • Ferritins