Long-Term Humoral Immune Response in Persons with Asymptomatic or Mild SARS-CoV-2 Infection, Vietnam

Emerg Infect Dis. 2021 Feb;27(2):663-666. doi: 10.3201/eid2702.204226.

Abstract

Antibody response against nucleocapsid and spike proteins of SARS-CoV-2 in 11 persons with mild or asymptomatic infection rapidly increased after infection. At weeks 18-30 after diagnosis, all remained seropositive but spike protein-targeting antibody titers declined. These data may be useful for vaccine development.

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-2 spike protein; asymptomatic coronavirus disease; immune response; neutralizing antibodies; respiratory infections; viruses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood
  • Antibodies, Viral / immunology
  • Asymptomatic Infections
  • COVID-19 / blood
  • COVID-19 / immunology*
  • COVID-19 / virology
  • Child
  • Female
  • Humans
  • Immunity, Humoral*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nucleocapsid Proteins / blood
  • Nucleocapsid Proteins / immunology
  • SARS-CoV-2 / immunology*
  • Spike Glycoprotein, Coronavirus / blood
  • Spike Glycoprotein, Coronavirus / immunology
  • Time Factors
  • Vietnam
  • Young Adult

Substances

  • Antibodies, Viral
  • Nucleocapsid Proteins
  • Spike Glycoprotein, Coronavirus