Proton Transfer and SN 2 Reactions as Steps of Fast Selenol and Thiol Oxidation in Proteins: A Model Molecular Study Based on GPx

Chempluschem. 2021 Apr;86(4):524. doi: 10.1002/cplu.202000781. Epub 2021 Jan 26.

Abstract

Invited for this month's cover are collaborating groups from Università degli Studi di Padova, Vrije Universiteit Amsterdam, and Universidad de la República Uruguay. The cover picture shows two lorries along the road directed to the destination 'H2 O2 reduction', and the selenol (SeH) lorry is faster than the thiol (SH) lorry. This cartoon represents the situation of glutathione peroxidase (GPx), in which the presence of selenium rather than sulfur warrants a significantly faster hydroperoxide reduction along the same mechanistic path. Read the full text of the article at 10.1002/cplu.202000660.

MeSH terms

  • Glutathione Peroxidase
  • Protons
  • Selenium Compounds*
  • Sulfhydryl Compounds*

Substances

  • Protons
  • Selenium Compounds
  • Sulfhydryl Compounds
  • selenol
  • Glutathione Peroxidase