Genetic characterization of acute myeloid leukemia patients with mutations in IDH1/2 genes

Pamela Acha; Montserrat Hoyos; Marta Pratcorona; Francisco Fuster-Tormo; Laura Palomo; Esther Ortega; Lurdes Zamora; Susana Vives; Isabel Granada; Julia Montoro; Antoni Garcia; Montserrat Arnan; Marta Cervera; Marta Canet; David Gallardo; Leonor Arenillas; Jordi Esteve; Joan Baragay; Olga Salamero; Cristina Motlló; Xavier Ortín; Jordi Sierra; Francesc Solé

doi:10.1016/j.leukres.2020.106492

Genetic characterization of acute myeloid leukemia patients with mutations in IDH1/2 genes

Leuk Res. 2021 Feb:101:106492. doi: 10.1016/j.leukres.2020.106492. Epub 2021 Jan 11.

Authors

Pamela Acha¹, Montserrat Hoyos², Marta Pratcorona², Francisco Fuster-Tormo¹, Laura Palomo¹, Esther Ortega¹, Lurdes Zamora³, Susana Vives³, Isabel Granada³, Julia Montoro⁴, Antoni Garcia⁵, Montserrat Arnan⁶, Marta Cervera⁷, Marta Canet⁸, David Gallardo⁹, Leonor Arenillas¹⁰, Jordi Esteve¹¹, Joan Baragay¹², Olga Salamero⁴, Cristina Motlló¹³, Xavier Ortín¹⁴, Jordi Sierra², Francesc Solé¹⁵

Affiliations

¹ MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
² Hematology Service, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
³ Hematology Service, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras, Universitat Autònoma de Barcelona, Badalona, Spain.
⁴ Hospital Universitari, Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain.
⁵ Hematology Service, Hospital Universitari Arnau Vilanova, Lleida, Spain.
⁶ Hematology Service, Institut Català d'Oncologia-Hospital Duran i Reynals, Barcelona, Spain.
⁷ Hematology Service, Hospital Universitari Joan XXIII de Tarragona, Tarragona, Spain.
⁸ Hematology Service, Hospital Universitari Mútua Terrassa, Terrassa, Spain.
⁹ Institut Català d'Oncologia-Hospital Dr. Josep trueta, Girona, Spain.
¹⁰ Hematology Service, Hospital del Mar, Barcelona, Spain.
¹¹ Hematology Service, Hospital Clínic de Barcelona, Barcelona, Spain.
¹² Hematology Service, Hospital Universitario Son Llàtzer, Palma de Mallorca, Spain.
¹³ Hematology Service, Fundació Althaia, Manresa, Spain.
¹⁴ Hematology Service, Hospital de Tortosa Verge de la Cinta, Tortosa, Spain.
¹⁵ MDS Research Group, Institut de Recerca Contra la Leucèmia Josep Carreras, Institut Català d'Oncologia-Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain. Electronic address: fsole@carrerasresearch.org.

PMID: 33494038
DOI: 10.1016/j.leukres.2020.106492

No abstract available

Publication types

Clinical Trial
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Female
Humans
Isocitrate Dehydrogenase / genetics*
Leukemia, Myeloid, Acute* / enzymology
Leukemia, Myeloid, Acute* / genetics
Male
Mutation*
Neoplasm Proteins / genetics*

Substances

Neoplasm Proteins
IDH2 protein, human
Isocitrate Dehydrogenase
IDH1 protein, human