The relationship between exposure to general anesthetic agents and the risk of developing an impulse control disorder

Linghua Xie; Yuhan Hu; Dandan Yan; P McQuillan; Yue Liu; Shengmei Zhu; Zhirui Zhu; Yilei Jiang; Zhiyong Hu

doi:10.1016/j.phrs.2021.105440

The relationship between exposure to general anesthetic agents and the risk of developing an impulse control disorder

Pharmacol Res. 2021 Mar:165:105440. doi: 10.1016/j.phrs.2021.105440. Epub 2021 Jan 23.

Authors

Linghua Xie¹, Yuhan Hu², Dandan Yan¹, P McQuillan³, Yue Liu⁴, Shengmei Zhu¹, Zhirui Zhu⁵, Yilei Jiang⁵, Zhiyong Hu⁶

Affiliations

¹ Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² Department of Cell Biology, Yale University, New Haven, CT, USA.
³ Department of Anesthesiology, Penn State Hershey Medical Centre, Penn State College of Medicine, Hershey, PA, USA.
⁴ Department of Anesthesiology, The Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁵ Department of Anesthesiology, The Children Hospital, Zhejiang University School of Medicine, Hangzhou, China.
⁶ Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: huzhiyong777@zju.edu.cn.

PMID: 33493656
DOI: 10.1016/j.phrs.2021.105440

Abstract

Most studies examining the effect of extended exposure to general anesthetic agents (GAAs) have demonstrated that extended exposure induces both structural and functional changes in the central nervous system. These changes are frequently accompanied by neurobehavioral changes that include impulse control disorders that are generally characterized by deficits in behavioral inhibition and executive function. In this review, we will.

Keywords: General anesthetic agents; Glia cells; Impulsive behavior; Neural circuits; Neurotransmitters.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Anesthetics, General / administration & dosage
Anesthetics, General / adverse effects*
Animals
Brain / drug effects*
Brain / metabolism
Disruptive, Impulse Control, and Conduct Disorders / chemically induced*
Disruptive, Impulse Control, and Conduct Disorders / diagnosis
Disruptive, Impulse Control, and Conduct Disorders / metabolism
Humans
Nerve Net / drug effects*
Nerve Net / metabolism
Risk Factors

Substances

Anesthetics, General