Recurrence of Port-Wine Stain After Photodynamic Therapy: A Case Report with a 22-Year Follow-Up

Yue Han; Wenxin Yu; Hanru Ying; Xiaolin Zhang; Lizhen Wang; Qingqing Cen; Jiafang Zhu; Gang Ma; Xiaoxi Lin

doi:10.1089/photob.2020.4856

Recurrence of Port-Wine Stain After Photodynamic Therapy: A Case Report with a 22-Year Follow-Up

Photobiomodul Photomed Laser Surg. 2021 Dec;39(12):795-798. doi: 10.1089/photob.2020.4856. Epub 2021 Jan 25.

Authors

Yue Han^{1

2

3}, Wenxin Yu^{1

2}, Hanru Ying¹, Xiaolin Zhang¹, Lizhen Wang⁴, Qingqing Cen¹, Jiafang Zhu², Gang Ma^{1

2}, Xiaoxi Lin^{1

2}

Affiliations

¹ Department of Plastic and Reconstructive Surgery and Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Department of Laser and Aesthetic Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
³ Departments of Burn and Plastic Surgery, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Shanghai, China.
⁴ Shanghai Key Laboratory of Stomatology, Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

PMID: 33493015
DOI: 10.1089/photob.2020.4856

Abstract

Objective: Recurrence or redarkening of port-wine stain (PWS) after laser treatment occurs frequently. Background: Vascular-targeted photodynamic therapy (PDT) is an alternative adjuvant treatment for PWS. Methods: We report the first case of PWS recurrence after PDT with a 22-year follow-up. Results: Histological analysis was performed to indicate the possible mechanisms of PWS recurrence. Conclusions: This case demonstrates the possibility of PWS recurrence and suggests that patients be notified of this possibility before treatment.

Keywords: follow-up; histology; photodynamic therapy; port-wine stain; recurrence.

Publication types

Case Reports

MeSH terms

Follow-Up Studies
Humans
Photochemotherapy*
Port-Wine Stain* / drug therapy