Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Jalal Bohlouli; Iman Namjoo; Mohammad Borzoo-Isfahani; Mohammad Ali Hojjati Kermani; Zakiyeh Balouch Zehi; Amir Reza Moravejolahkami

doi:10.1016/j.heliyon.2021.e05925

Effect of probiotics on oxidative stress and inflammatory status in diabetic nephropathy: A systematic review and meta-analysis of clinical trials

Heliyon. 2021 Jan 10;7(1):e05925. doi: 10.1016/j.heliyon.2021.e05925. eCollection 2021 Jan.

Authors

Jalal Bohlouli¹, Iman Namjoo², Mohammad Borzoo-Isfahani², Mohammad Ali Hojjati Kermani³, Zakiyeh Balouch Zehi⁴, Amir Reza Moravejolahkami⁵

Affiliations

¹ Department of Nutrition, Nutrition and Food Security Research Centre, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
² Department of Community Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
³ Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.
⁴ Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁵ Department of Clinical Nutrition, School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Abstract

This systematic review and meta-analysis was performed to evaluate the effect of probiotics on serum high sensitivity-C reactive protein (hs-CRP) and oxidative stress biomarkers among patients with Diabetic Nephropathy (DN). Electronic databases were searched through May 10, 2020. Seven trials that included 340 patients were identified for analysis. Meta-analysis indicated that probiotics significantly reduced hs-CRP (WMD = -1.53 mg/L; 95% CI = -2.38, -0.69; P < 0.001) and Malondialdehyde (MDA) (WMD = -0.62 ɥmol/L; 95% CI = -1.18, -0.06; P = 0.030) levels in DN patients, whereas they increased Glutathione (GSH) (WMD = 73.84 ɥmol/L; 95% CI = 24.3, 123.29; P = 0.003) and Total Antioxidant Capacity (TAC) (WMD = 26.54 mmol/L; 95% CI = 6.23, 46.85; P = 0.010). Therefore, probiotics may improve hs-CRP and oxidative stress biomarkers in DN population.

Keywords: C-reactive protein; Diabetic nephropathies; Meta-analysis; Oxidative stress; Probiotics.

Publication types

Review