Revisiting Functional Connectivity for Infraslow Scale-Free Brain Dynamics Using Complex Wavelets

Daria La Rocca; Herwig Wendt; Virginie van Wassenhove; Philippe Ciuciu; Patrice Abry

doi:10.3389/fphys.2020.578537

Revisiting Functional Connectivity for Infraslow Scale-Free Brain Dynamics Using Complex Wavelets

Front Physiol. 2021 Jan 7:11:578537. doi: 10.3389/fphys.2020.578537. eCollection 2020.

Authors

Daria La Rocca^{1

2}, Herwig Wendt³, Virginie van Wassenhove^{1

4}, Philippe Ciuciu^{1

2}, Patrice Abry⁵

Affiliations

¹ CEA, NeuroSpin, University of Paris-Saclay, Paris, France.
² Inria Saclay Île-de-France, Parietal, University of Paris-Saclay, Paris, France.
³ IRIT, CNRS, University of Toulouse, Toulouse, France.
⁴ INSERM U992, Collège de France, University of Paris-Saclay, Paris, France.
⁵ Univ. Lyon, ENS de Lyon, Univ. Claude Bernard, CNRS, Laboratoire de Physique, Lyon, France.

Abstract

The analysis of human brain functional networks is achieved by computing functional connectivity indices reflecting phase coupling and interactions between remote brain regions. In magneto- and electroencephalography, the most frequently used functional connectivity indices are constructed based on Fourier-based cross-spectral estimation applied to specific fast and band-limited oscillatory regimes. Recently, infraslow arrhythmic fluctuations (below the 1 Hz) were recognized as playing a leading role in spontaneous brain activity. The present work aims to propose to assess functional connectivity from fractal dynamics, thus extending the assessment of functional connectivity to the infraslow arrhythmic or scale-free temporal dynamics of M/EEG-quantified brain activity. Instead of being based on Fourier analysis, new Imaginary Coherence and weighted Phase Lag indices are constructed from complex-wavelet representations. Their performances are first assessed on synthetic data by means of Monte-Carlo simulations, and they are then compared favorably against the classical Fourier-based indices. These new assessments of functional connectivity indices are also applied to MEG data collected on 36 individuals both at rest and during the learning of a visual motion discrimination task. They demonstrate a higher statistical sensitivity, compared to their Fourier counterparts, in capturing significant and relevant functional interactions in the infraslow regime and modulations from rest to task. Notably, the consistent overall increase in functional connectivity assessed from fractal dynamics from rest to task correlated with a change in temporal dynamics as well as with improved performance in task completion, which suggests that the complex-wavelet weighted Phase Lag index is the sole index is able to capture brain plasticity in the infraslow scale-free regime.

Keywords: MEG data; arrhythmic; complex-wavelet; fractal connectivity; functional connectivity; human brain temporal dynamics; infraslow; scale-free.