Pregnancy predictors in unexplained infertility after intrauterine insemination

J Gynecol Obstet Hum Reprod. 2021 Oct;50(8):102071. doi: 10.1016/j.jogoh.2021.102071. Epub 2021 Jan 21.

Abstract

Background: Intrauterine insemination (IUI) is a first-line treatment for unexplained infertility (UI). There was a compelling need for the improvement of pregnancy rate in females with UI.

Objective: To explore the pregnancy predictors in cases of UI undergoing IUI.

Method: A total of 212 couples who underwent 446 IUI cycles were involved the study. Different factors were grouped to explore the influencing factors of IUI for UI.

Result: Female age and somking affected pregnancy outcomes. As the number of treatment cycles increased, the pregnancy rate increased. The BMI, treatment regimens, type of infertility, endometrium, and timing insemination have no significant prognostic value.

Conclusion: Apart from the number of treatment cycles, somking, and female age, no other factors had prognostic value. More studies and samples are necessary to evaluate whether other factors affect conception.

Keywords: Intrauterine insemination; Pregnancy; Unexplained infertility.

Publication types

  • Review

MeSH terms

  • Adult
  • Chi-Square Distribution
  • Female
  • Humans
  • Infertility, Female / diagnosis
  • Infertility, Female / etiology*
  • Insemination, Artificial / methods
  • Insemination, Artificial / statistics & numerical data*
  • Pregnancy
  • Pregnancy Outcome / epidemiology
  • Retrospective Studies
  • Time Factors