Acute Lymphoblastic Leukemia Cell Lines in Immunology Research

Salvador Valle-Reyes; Oxana Dobrovinskaya; Rosana Pelayo; Michael Schnoor

doi:10.1016/j.it.2020.12.007

Acute Lymphoblastic Leukemia Cell Lines in Immunology Research

Trends Immunol. 2021 Mar;42(3):182-185. doi: 10.1016/j.it.2020.12.007. Epub 2021 Jan 21.

Authors

Salvador Valle-Reyes¹, Oxana Dobrovinskaya², Rosana Pelayo³, Michael Schnoor⁴

Affiliations

¹ Department for Molecular Biomedicine, CINVESTAV-IPN, 07360 Mexico City, Mexico.
² Laboratory of Immunobiology and Ionic Transport Regulation, University Center for Biomedical Research, University of Colima, 28030, Colima, Mexico.
³ Eastern Biomedical Research Center, CIBIOR, Instituto Mexicano del Seguro Social, Delegación Puebla, Mexico.
⁴ Department for Molecular Biomedicine, CINVESTAV-IPN, 07360 Mexico City, Mexico. Electronic address: mschnoor@cinvestav.mx.

PMID: 33485795
DOI: 10.1016/j.it.2020.12.007

Abstract

A considerable portion of our knowledge on T and B cell biology is acquired from research using acute lymphoblastic leukemia (ALL) cell lines, which are invaluable tools used in many immunology and leukemia studies. Here, we discuss the advantages and limitations of ALL cell lines and provide guidelines on their proper usage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

B-Lymphocytes
Cell Line
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma*