Predisposition to cancer in children and adolescents

Christian P Kratz; Marjolijn C Jongmans; Hélène Cavé; Katharina Wimmer; Sam Behjati; Lea Guerrini-Rousseau; Till Milde; Kristian W Pajtler; Lisa Golmard; Marion Gauthier-Villars; Rosalyn Jewell; Catriona Duncan; Eamonn R Maher; Laurence Brugieres; Kathy Pritchard-Jones; Franck Bourdeaut

doi:10.1016/S2352-4642(20)30275-3

Predisposition to cancer in children and adolescents

Lancet Child Adolesc Health. 2021 Feb;5(2):142-154. doi: 10.1016/S2352-4642(20)30275-3.

Authors

Christian P Kratz¹, Marjolijn C Jongmans², Hélène Cavé³, Katharina Wimmer⁴, Sam Behjati⁵, Lea Guerrini-Rousseau⁶, Till Milde⁷, Kristian W Pajtler⁷, Lisa Golmard⁸, Marion Gauthier-Villars⁸, Rosalyn Jewell⁹, Catriona Duncan¹⁰, Eamonn R Maher¹¹, Laurence Brugieres⁶, Kathy Pritchard-Jones¹², Franck Bourdeaut¹³

Affiliations

¹ Paediatric Haematology and Oncology, Hannover Medical School, Hannover, Germany.
² Princess Máxima Center for Paediatric Oncology, Utrecht, Netherlands; Department of Genetics, University Medical Center Utrecht, Princess Máxima Center for Paediatric Oncology, Utrecht, Netherlands.
³ Department of Genetics, Assistance Publique Hôpitaux de Paris-Robert Debre University Hospital, Paris, France; Denis Diderot School of Medicine, University of Paris, Paris, France; Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1131, Institut de Recherche Saint Louis, Paris, France.
⁴ Institute of Human Genetics, Medical University of Innsbruck, Innsbruck, Austria.
⁵ Wellcome Sanger Institute, Cambridge, UK; Department of Paediatrics, University of Cambridge, Cambridge, UK.
⁶ Department of Children and Adolescents Oncology, Gustave Roussy, Villejuif, Paris, France.
⁷ Clinical Cooperation Unit Paediatric Oncology, German Cancer Research Center and German Consortium for Translational Cancer Research, Heidelberg, Germany; KiTZ Clinical Trial Unit, Department of Paediatric Haematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany; Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
⁸ Department of Genetics, Institut Curie, Paris, France; Paris Sciences Lettres Research University, Paris, France.
⁹ Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds Teaching Hospitals NHS Trust, Leeds, UK.
¹⁰ Paediatric Oncology, London, UK.
¹¹ Department of Medical Genetics, University of Cambridge, Cambridge, UK; NIHR Cambridge Biomedical Research Centre and Cancer Research UK Cambridge Centre, Cambridge Biomedical Campus, Cambridge, UK.
¹² Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK; UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
¹³ SIREDO Paediatric Cancer Center, Institut Curie, Paris, France; INSERM U830, Laboratory of Translational Research in Paediatric Oncology, Institut Curie, Paris, France; Paris Sciences Lettres Research University, Paris, France. Electronic address: franck.bourdeaut@curie.fr.

PMID: 33484663
DOI: 10.1016/S2352-4642(20)30275-3

Abstract

Childhood malignancies are rarely related to known environmental exposures, and it has become increasingly evident that inherited genetic factors play a substantial causal role. Large-scale sequencing studies have shown that approximately 10% of children with cancer have an underlying cancer predisposition syndrome. The number of recognised cancer predisposition syndromes and cancer predisposition genes are constantly growing. Imaging and laboratory technologies are improving, and knowledge of the range of tumours and risk of malignancy associated with cancer predisposition syndromes is increasing over time. Consequently, surveillance measures need to be constantly adjusted to address these new findings. Management recommendations for individuals with pathogenic germline variants in cancer predisposition genes need to be established through international collaborative studies, addressing issues such as genetic counselling, cancer prevention, cancer surveillance, cancer therapy, psychological support, and social-ethical issues. This Review represents the work by a group of experts from the European Society for Paediatric Oncology (SIOPE) and aims to summarise the current knowledge and define future research needs in this evolving field.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Adolescent
Child
Female
Genetic Predisposition to Disease*
Genetic Testing
Humans
Male
Medical Oncology / methods
Neoplasms / genetics*
Neoplasms / prevention & control
Risk Assessment

Abstract

Publication types

MeSH terms

Grants and funding