Calcineurin: A star is reborn

Huiming Li; Patrick G Hogan

doi:10.1016/j.ceca.2020.102324

Calcineurin: A star is reborn

Cell Calcium. 2021 Mar:94:102324. doi: 10.1016/j.ceca.2020.102324. Epub 2021 Jan 12.

Authors

Huiming Li¹, Patrick G Hogan²

Affiliations

¹ Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA, 02115, USA.
² La Jolla Institute for Immunology, La Jolla, CA, 92037, USA; Moores Cancer Center, University of California-San Diego, La Jolla, CA, 92093, USA. Electronic address: phogan@lji.org.

Abstract

The protein phosphatase calcineurin has long been familiar to the calcium community, but the definition of its physiological substrates has been far from complete. A new study rectifies this deficiency and sets the stage for new insights into the role of calcineurin in diverse cellular processes.

Keywords: Calcineurin; Docking motif; LxVP; Phage display; PxIxIT; SLiM; Substrate.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Calcineurin / chemistry
Calcineurin / metabolism*
Humans
NFATC Transcription Factors / metabolism
Signal Transduction
Substrate Specificity

Substances

NFATC Transcription Factors
Calcineurin

Abstract

Publication types

MeSH terms

Substances

Grants and funding