To Degrade a MicroRNA, Destroy Its Argonaute Protein

Pei-Hsuan Wu; Phillip D Zamore

doi:10.1016/j.molcel.2020.12.043

To Degrade a MicroRNA, Destroy Its Argonaute Protein

Mol Cell. 2021 Jan 21;81(2):223-225. doi: 10.1016/j.molcel.2020.12.043.

Authors

Pei-Hsuan Wu¹, Phillip D Zamore²

Affiliations

¹ Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: pei-hsuan.wu@umassmed.edu.
² Howard Hughes Medical Institute and RNA Therapeutics Institute, University of Massachusetts Medical School, 368 Plantation Street, Worcester, MA 01605, USA. Electronic address: phillip.zamore@umassmed.edu.

PMID: 33482091
DOI: 10.1016/j.molcel.2020.12.043

Abstract

Han et al. (2020) and Shi et al. (2020) report that the E3 ubiquitin ligase ZSWIM8 senses when an RNA and an Argonaute protein-bound microRNA are extensively base paired and directs Argonaute destruction by the proteasome. The result is degradation of the microRNA.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Argonaute Proteins / genetics
Argonaute Proteins / metabolism
MicroRNAs* / genetics
Proteasome Endopeptidase Complex / metabolism
Ubiquitin* / metabolism
Ubiquitin-Protein Ligases / metabolism

Substances

Argonaute Proteins
MicroRNAs
Ubiquitin
Ubiquitin-Protein Ligases
Proteasome Endopeptidase Complex

Abstract

Publication types

MeSH terms

Substances

Grants and funding