On the basic of the fact that all signals in the practical system are always bounded, this paper proposes a 4-degree-of-freedom (DoF) anti-windup scheme for saturated systems with parametric uncertainty. A fairly straightforward tuning rule is introduced to the robust stability analysis for the proposed anti-windup structure under the framework of IQC (Integral Quadratic Constraint). And the sufficient stability conditions are derived to check the reasonable definiteness of the related transfer function. Moreover, the control design for disturbance response and set-point tracking response are two separate part in this proposed scheme. Numerical example demonstrates the effectiveness and the considerable performance improvement of the anti-windup compensator that is designed by the proposed technique.