Demystifying Cell Cycle Arrest by HIV-1 Vif

Daniel J Salamango; Reuben S Harris

doi:10.1016/j.tim.2021.01.001

Demystifying Cell Cycle Arrest by HIV-1 Vif

Trends Microbiol. 2021 May;29(5):381-384. doi: 10.1016/j.tim.2021.01.001. Epub 2021 Jan 19.

Authors

Daniel J Salamango¹, Reuben S Harris²

Affiliations

¹ Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: dsalaman@umn.edu.
² Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA; Howard Hughes Medical Institute, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: rsh@umn.edu.

Abstract

Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

Keywords: G2/M cell cycle arrest; HIV-1; PPP2R5; Vif; host–pathogen interaction.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Cell Cycle Checkpoints*
HIV-1 / genetics
HIV-1 / metabolism*
HIV-1 / pathogenicity
Host-Pathogen Interactions
Protein Phosphatase 2 / genetics
Protein Phosphatase 2 / metabolism
vif Gene Products, Human Immunodeficiency Virus / genetics*
vif Gene Products, Human Immunodeficiency Virus / metabolism*

Substances

PPP2R5A protein, human
vif Gene Products, Human Immunodeficiency Virus
vif protein, Human immunodeficiency virus 1
vif protein, Human immunodeficiency virus 2
Protein Phosphatase 2

Abstract

Publication types

MeSH terms

Substances

Grants and funding