NUT carcinoma is a rare, high lethal cancer which feature as the rearrangement of the nuclear protein in testis (NUT) gene on chromosome 15q14, and its pathogenesis and treatment is not yet clear, the prognosis is poor. Due to NUT carcinoma often occurred on the middle position of the body, such as eyes, nose and palate, mediastinum, so it is also called NUT midline carcinoma (NMC). In this case, we report a 70 years old man who was diagnosed as primary pulmonary NUT carcinoma in the Department of Thoracic Oncology, West China Hospital of Sichuan University. A tumor was found at the left hilus pulmonis when his physical examination without any symptom. Postoperative pathological showed poorly differentiated carcinoma, confirmed by fluorescence in situ hybridization technique for the NUT carcinoma. After operation, chemotherapy, antiangiogenesis therapy, and radiotherapy were given, and he got a long lifetime. Combined with the literature review, we report the clinical and pathological features, and treatment strategies of the rare pulmonary NUT carcinoma case. .
【中文题目：肺NUT癌1例报告及文献复习】 【中文摘要：NUT癌是以染色体15q14上睾丸核蛋白（nuclear protein in testis, NUTM1）重排为特征的一种罕见的恶性程度极高的肿瘤，其发病机制及治疗方法目前尚不明确，其预后极差。因其好发部位主要集中在躯体中线位置，如眼眶、鼻腔、上颚、纵隔等，故又称为中线癌。四川大学华西医院胸部肿瘤科收治了1例肺NUT癌患者，为70岁老年男性，初诊为体检发现左肺门占位，术后病理提示低分化癌，经荧光标记的原位杂交技术证实为NUT癌，术后经化疗、抗血管治疗、放疗等综合治疗获得了较长的生存期。本文结合文献回顾报告了肺NUT癌这一少见实体瘤的临床、病理特征及治疗策略。 】 【中文关键词：肺肿瘤；放疗；化疗；生存期】.
Keywords: Chemotherapy; Lung neoplasms; Overall survival; Radiotherapy.