Fever is a common onset feature of MOG-IgG associated disorders (MOGAD)

Abstract

Background: Fever is a deceptive feature of autoimmune disorders. Although cases of MOG-IgG associated disorders (MOGAD) were rarely associated with fever, this association was not specifically described.

Methods: We report a case of MOGAD revealed by weeks of fever and meningitis. We reviewed the current literature to describe the association between fever and MOGAD.

Results: We analyzed 146 cases from the literature including ours. Fever was associated with 39% of MOGAD attacks and lasted more than a week in 74%. Fever was strongly associated with brain and spinal cord attacks, and with meningitis.

Conclusion: Among the various features of MOGAD, fever is a highly prevalent associated symptom that should be kept in mind.