The incidence of non-alcohol fatty liver disease (NAFLD) is increasing year by year, and the relevant cardiovascular events have become a major problem in chronic diseases management. The activation of innate immunity is closely related to the development of NAFLD. The immune cells include Kupffer cells, neutrophils, dendritic cells, and natural killer T cells, which acts through the activation of innate immunity-related signals mediated by pattern recognition receptors.
非酒精性脂肪性肝病(non-alcohol fatty liver disease，NAFLD)的发病率逐年升高，其所诱导的相关心血管事件等也成为目前慢性病管理的重大问题。固有免疫的激活与NAFLD的发生、发展密切相关，参与的免疫细胞为Kupffer细胞、中性粒细胞、树突状细胞及自然杀伤T淋巴细胞，并通过模式识别受体介导的固有免疫相关信号的激活而发挥作用。.
Keywords: innate immunity; new therapeutic targets; non-alcohol fatty liver disease; treatment.