Genetic Evaluation of Nosocomial Candida auris Transmission

J Clin Microbiol. 2021 Mar 19;59(4):e02252-20. doi: 10.1128/JCM.02252-20. Print 2021 Mar 19.

Abstract

Whole-genome sequences of Candida auris isolates from nosocomial and nonnosocomial infections were compared. The average numbers of single nucleotide variations were different between the two groups. The small amount of genetic variability between intra- or interhost isolates suggests recovery of all colonizing or infecting genomes for comparison is required for outbreaks.

Keywords: Candida auris; nosocomial transmission; whole-genome sequencing.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use
  • Candida* / genetics
  • Cross Infection* / epidemiology
  • Disease Outbreaks
  • Humans
  • Microbial Sensitivity Tests

Substances

  • Antifungal Agents