Harnessing brain development to understand brain tumours

Silvia Marino; Richard J Gilbertson

doi:10.1242/dev.193342

Harnessing brain development to understand brain tumours

Development. 2021 Jan 20;148(2):dev193342. doi: 10.1242/dev.193342.

Authors

Silvia Marino¹, Richard J Gilbertson^{2

3}

Affiliations

¹ Blizard Institute, Barts Brain Tumour Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, 4 Newark Street, London E1 2AT, UK s.marino@qmul.ac.uk.
² Department of Oncology, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.
³ CRUK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK.

Abstract

Brain tumours are the commonest solid neoplasms in children, accounting for one quarter of all childhood cancers. Our growing knowledge of basic developmental mechanisms has significantly contributed to understanding the pathogenesis of these tumours and is beginning to impact clinical decisions on how children with these diseases are treated.

Keywords: Diffuse intrinsic pontine glioma; Ependymoma; Medulloblastoma; Paediatric tumours.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Brain / embryology*
Brain / pathology
Brain Neoplasms / genetics
Brain Neoplasms / pathology*
Child
Humans
Models, Biological
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding