Characterization of crystalline forms of gaxilose, a diagnostic drug

Carbohydr Res. 2021 Jan:499:108232. doi: 10.1016/j.carres.2021.108232. Epub 2021 Jan 8.

Abstract

Lactose intolerance is a pathology caused by lactase enzyme deficiency, usually produced in the intestinal cells provoking symptoms as abdominal pain, bloating, diarrhea, gas and nausea. Gaxilose, 4-O-β-D galactopyranosyl-d-xylose, is used as a diagnostic drug for a non-invasive method for hypolactasia diagnosis. To date, no definitive guide for identifying gaxilose and distinguishing between crystalline forms is available. Data have been collected from a number of different analytical techniques in order to provide a full characterization of the compound and a simple method to discriminate between two solid forms.

Keywords: Crystal structure; Diagnostic drug; Enzyme; Lactose intolerance; NMR spectroscopy.

MeSH terms

  • Abdominal Pain / diagnosis*
  • Carbohydrate Conformation
  • Crystallization
  • Diarrhea / diagnosis*
  • Disaccharides / chemical synthesis
  • Disaccharides / chemistry*
  • Humans
  • Lactose Intolerance / diagnosis*
  • Nausea / diagnosis*
  • Powder Diffraction

Substances

  • Disaccharides
  • 4-O-galactopyranosylxylose