A 77-year-old woman, who underwent surgery for malignant melanoma of the nasal cavity 15 months prior and radiation and interferon-β therapy for local recurrence, presented with epigastric discomfort. PET-CT examination showed multiple intussusceptions due to small intestinal tumors. Four intussusceptions were detected during laparotomy, and she underwent partial resection of the small intestine. Pathological findings revealed small intestinal metastases that originated from malignant melanoma. Following administration of nivolumab, local recurrence disappeared, and she was well. Because the prognosis of malignant melanoma with systemic metastases has improved due to the administration of new drugs, such as nivolumab, the incidence of indications for surgery for metastatic melanomas of the gastrointestinal tract is expected to increase.