Comparison of efficacy of deep brain stimulation and focused ultrasound in parkinsonian tremor: a systematic review and network meta-analysis

Fabin Lin; Dihang Wu; Jiao Yu; Huidan Weng; Lina Chen; Fangang Meng; Ying Chen; Qinyong Ye; Guoen Cai

doi:10.1136/jnnp-2020-323656

Comparison of efficacy of deep brain stimulation and focused ultrasound in parkinsonian tremor: a systematic review and network meta-analysis

J Neurol Neurosurg Psychiatry. 2021 Jan 18:jnnp-2020-323656. doi: 10.1136/jnnp-2020-323656. Online ahead of print.

Authors

Fabin Lin^#^{1

2

3}, Dihang Wu^#^{1

2

3}, Jiao Yu^{1

2

4}, Huidan Weng^{1

2

4}, Lina Chen^{1

2

4}, Fangang Meng⁵, Ying Chen^{1

2

4}, Qinyong Ye^{6

2

4}, Guoen Cai^{6

2

3

4}

Affiliations

¹ Department of Neurology, Union Hospital, Fujian Medical University, Fuzhou, China.
² Institute or Neuroscience, Fujian Key Laboratory of Molecular Neurology, Fujian Medical University, Fuzhou, China.
³ Department of Clinical Medicine, Fujian Medical University, Fuzhou, China.
⁴ Institute of Clinical Neurology, Fujian Medical University, Fuzhou, China.
⁵ Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
⁶ Department of Neurology, Union Hospital, Fujian Medical University, Fuzhou, China cgessmu@fjmu.edu.cn unionqyye@163.com.

^# Contributed equally.

PMID: 33461975
DOI: 10.1136/jnnp-2020-323656

Abstract

To compare the efficacy of deep brain stimulation (DBS) and MRI-guided focused ultrasound (MRIgFUS) in parkinsonian tremor. We performed a network meta-analysis based on a Bayesian framework. We searched the literature for articles published between January 1990 and October 2020 using three databases: PubMed, Embase and Cochrane Library (The Cochrane Database of Systematic Reviews). A total of 24 studies were included in our analysis, comprising data from 784 participants. Our findings revealed similar efficacy of DBS and MRIgFUS in parkinsonian tremor suppression. Compared with internal globus pallidus (GPi)-MRIgFUS, GPi-DBS -1.84 (-6.44, 2.86), pedunculopontine nucleus (PPN)_DBS -3.28 (-9.28, 2.78), PPN and caudal zona incerta (cZI)-DBS 0.40 (-6.16, 6.87), subthalamic nucleus (STN)_DBS 0.89 (-3.48, 5.30), STN and cZI-DBS 1.99 (-4.74, 8.65), ventral intermediate nucleus(VIM)_DBS 1.75 (-2.87, 6.48), VIM_FUS 0.72 (-5.27, 6.43), cZI-DBS 0.27 (-4.75, 5.36) were no significantly difference. Compared with VIM-MRIgFUS, GPi-DBS -2.55(-6.94, 2.21), GPi-FUS -0.72 (-6.43, 5.27), PPN_DBS -4.01(-9.97, 2.11), PPN and cZI-DBS -0.32 (-6.73, 6.36), STN_DBS 0.16 (-3.98, 4.6), STN and cZI-DBS 1.31(-5.18,7.87), VIM-DBS 1.00(-3.41, 5.84)and cZI-DBS -0.43 (-5.07, 4.68) were no significantly difference. With respect to the results for the treatment of motor symptoms, GPi-DBS, GPi-MRIgFUS, STN-DBS and cZI-DBS were significantly more efficacious than baseline (GPi-DBS 15.24 (5.79, 24.82), GPi-MRIgFUS 13.46 (2.46, 25.10), STN-DBS 19.62 (12.19, 27.16), cZI-DBS 14.18 (1.73, 26.89). The results from the surface under the cumulative ranking results showed that STN-DBS ranked first, followed by combined PPN and cZI-DBS, and PPN-DBS ranked last. MRIgFUS, an efficacious intervention for improving parkinsonian tremor, has not demonstrated to be inferior to DBS in parkinsonian tremor suppression. Hence, clinicians should distinguish individual patients' symptoms to ensure that the appropriate intervention and therapeutic approach are applied.

Keywords: deep brain stimulation; focused ultrasound; meta-analysis; parkinson’s disease; systematic review.

Publication types

Review