Our ongoing interest in the relationships between chemical contents and genetic diversity of the nudibranch Phyllidiella pustulosa and related species found in Okinawa led to identification of a series of nitrogenous sesquiterpenoids. Among them, two new compounds 1 and 2 were elucidated after spectroscopic analysis. Their structures and cytotoxicity against three cell lines are described here.
Keywords: Phyllidiella pustulosa; biodiversity; cytotoxic activity; nitrogenous sesquiterpenoid.