Incidence and Impact of Parvovirus B19 Infection in Seronegative Solid Organ Transplant Recipients

J Infect Dis. 2021 Sep 1;224(5):865-869. doi: 10.1093/infdis/jiab024.

Abstract

Routine monitoring of parvovirus B19 (B19V) the first 6 months posttransplantation was performed in 241 seronegative solid organ transplant (SOT) recipients. Incidence rates during the first month and the second to sixth months posttransplantation were 1.2 (95% confidence interval [CI], .33-3.2) and 0.21 (95% CI, .06-.57) per 100 recipients per month, respectively. Of the 6 SOT recipients with positive B19V polymerase chain reaction, 3 (50%) were admitted to hospital and 2 (33%) were treated with intravenous immunoglobulin. Thus, routine monitoring of B19V in seronegative SOT recipients may not be necessary. Targeted screening 1 month posttransplantation and screening upon clinical suspicion could be an alternative strategy.

Keywords: human; incidence; organ transplant; parvovirus B19; polymerase chain reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cohort Studies
  • DNA, Viral / blood
  • Erythema Infectiosum / complications
  • Erythema Infectiosum / diagnosis
  • Erythema Infectiosum / epidemiology
  • Female
  • Humans
  • Immunocompromised Host*
  • Incidence
  • Male
  • Middle Aged
  • Organ Transplantation* / adverse effects
  • Parvoviridae Infections / complications*
  • Parvoviridae Infections / diagnosis
  • Parvoviridae Infections / epidemiology*
  • Parvovirus B19, Human / genetics
  • Parvovirus B19, Human / isolation & purification*
  • Polymerase Chain Reaction
  • Prospective Studies
  • Sequence Analysis, DNA
  • Transplants

Substances

  • DNA, Viral