Exuberant bullous vasculitis associated with SARS-CoV-2 infection

IDCases. 2021:23:e01047. doi: 10.1016/j.idcr.2021.e01047. Epub 2021 Jan 12.

Abstract

We described a case of exuberant cutaneous small-vessel vasculitis in a 27-year-old male with mild CoVID-19 in Brazil. The patient presented painful purpuric papules and vesicobullous lesions with hemorrhagic content located in the larger amount in the lower limbs and, to a lesser extent in the region of the back and upper limbs, saving palms and soles of the feet. Influenza-like syndrome with anosmia and ageusia was reported seven days before the skin lesions. A real-time reverse transcription polymerase chain reaction was positive on a nasopharyngeal swab for SARS-CoV-2. Histopathological study showed leukocytoclastic cutaneous vasculitis affecting small vessels and microthrombi occluding some vessels. The patient presented an improvement in skin lesions by the fifth day of prednisone therapy. This case highlights the importance of the SARS-CoV-2 test in investigating the etiology of cutaneous vasculitis during this pandemic.

Keywords: COVID-19; CSVV, cutaneous small-vessel vasculitis; CoVID-19, coronavirus disease; Coronavirus 2019; Coronavirus infections; Cutaneous leukocytoclastic vasculitis; LCV, leukocytoclastic cutaneous vasculitis; SARS-CoV-2; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; rRT-PCR, real-time reverse transcription polymerase chain reaction.

Publication types

  • Case Reports