Amphiphilic Polymer-Modified Uniform CuFeSe2 Nanoparticles for CT/MR Dual-Modal Imaging

Contrast Media Mol Imaging. 2020 Dec 30:2020:4891325. doi: 10.1155/2020/4891325. eCollection 2020.

Abstract

Recently, magnetic photothermal nanomaterials have attracted much attention in the diagnosis and treatment of cancer. In this study, we developed the ultrasmall magnetic CuFeSe2 nanoparticles for CT/MR dual-modal imaging. By controlling the reaction time and condition, CuFeSe2 nanoparticles were synthesized by a simple directly aqueous method. After modification with copolymer methoxy polyethylene glycol-polycaprolactone (MPEG-PCL), the obtained MPEG-PCL@CuFeSe2 nanoparticles showed excellent water solubility, colloidal stability, and biocompatibility. In addition, they also exhibited superparamagnetism and X-ray's characteristics. For these properties, they will become ideal nanomaterials for CT/MR dual-modal imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / pathology*
  • Cell Proliferation
  • Copper / chemistry*
  • Female
  • Humans
  • Iron / chemistry*
  • Magnetic Resonance Imaging / methods*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Multimodal Imaging / methods
  • Nanoparticles / administration & dosage
  • Nanoparticles / chemistry*
  • Polymers / chemistry*
  • Selenium Compounds / chemistry*
  • Tomography, X-Ray Computed / methods*
  • Tumor Cells, Cultured
  • Xenograft Model Antitumor Assays

Substances

  • Polymers
  • Selenium Compounds
  • Copper
  • Iron