Objective: To explore the relationship between premature atrial complexes (PACs) and recurrence of atrial fibrillation (AF). Methods: Published literature was searched in PubMed, Embase, Web of Science, Cochrane, Weipu, China national knowledge infrastructure, Wanfang and China Biology Medicine disc up to 25 March 2020. RevMan5.3 software was used to analyzed the data and publication bias was performed by Stata 15.1. Results: A total of 8 studies were identified, including 1 252 AF patients with a mean age of 61.67 years, and male patients accounted for 70.6%. During follow-up, AF recurred in 425 cases. Meta-analysis showed that frequent PACs was an independent risk factor for recurrence of AF (HR=2.64, 95%CI:1.40-4.97). Subgroup analyses showed that PACs not only increasedthe risk of recurrence of AF after electrical cardioversion (HR=2.38, 95%CI:1.25-4.51), but also significantly increased the risk of recurrence of AF after catheter ablation cardioversion (HR=2.90, 95%CI:1.11-7.60). Conclusions: PACs is significantly associated with AF recurrence.
目的： 探讨房性早搏（简称房早）与心房颤动（简称房颤）复发的相关性。 方法： 系统检索建库至2020年3月25日PubMed、Embase、Web of Science、Cochrane、维普、中国知网、万方及中国生物医学文献数据库关于房早与房颤复发相关性的研究。应用RevMan5.3软件制作森林图，应用Stata 15.1软件进行发表偏倚检验。 结果： 共纳入8项研究，共计1 252例房颤患者，425例复发，参与者平均年龄61.67岁，男性占70.6%。荟萃分析结果显示频发房早是房颤复发的独立危险因素（HR=2.64，95%CI：1.40~4.97），亚组分析显示房早不仅增加电复律后房颤复发风险（HR=2.38，95%CI：1.25~4.51），且显著增加导管消融复律后房颤复发风险（HR=2.90，95%CI：1.11~7.60）。 结论： 房早与房颤复律后的复发显著相关。.
Keywords: Atrial fibrillation; Meta-analysis; Premature atrial complex; Recurrence.