Biomaterial-based extracellular vesicle delivery for therapeutic applications

Vishnu Priya Murali; Christina A Holmes

doi:10.1016/j.actbio.2021.01.010

Biomaterial-based extracellular vesicle delivery for therapeutic applications

Acta Biomater. 2021 Apr 1:124:88-107. doi: 10.1016/j.actbio.2021.01.010. Epub 2021 Jan 14.

Authors

Vishnu Priya Murali¹, Christina A Holmes²

Affiliations

¹ Department of Chemical and Biomedical Engineering, College of Engineering, Florida A&M University-Florida State University, 2525 Pottsdamer Street, Room A131, Tallahassee, FL 32310, USA. Electronic address: vmurali@eng.famu.fsu.edu.
² Department of Chemical and Biomedical Engineering, College of Engineering, Florida A&M University-Florida State University, 2525 Pottsdamer Street, Room A131, Tallahassee, FL 32310, USA. Electronic address: caholmes@eng.famu.fsu.edu.

PMID: 33454381
DOI: 10.1016/j.actbio.2021.01.010

Abstract

Extracellular vesicle (EV)- based therapies have been successfully tested in preclinical models for several biomedical applications, including tissue engineering, drug delivery and cancer therapy. However, EVs are most commonly delivered via local or systemic injection, which results in rapid clearance. In order to prolong the retention of EVs at target site and improve their therapeutic efficacy, biomaterial-based delivery systems are being investigated. This review discusses the various biomaterial-based systems that have been used to deliver EVs for therapeutic applications, specifically highlighting any strategies for controlled release. Further, challenges to clinical translation of biomaterial-based EV delivery systems are also discussed.

Keywords: Biomaterials; Drug delivery; Extracellular vesicles; Regenerative medicine; Tissue engineering.

Publication types

Review

MeSH terms

Biocompatible Materials*
Drug Delivery Systems
Extracellular Vesicles*
Tissue Engineering

Substances

Biocompatible Materials