Deep vein thrombosis with pulmonary thromboembolism in a case of severe COVID-19 pneumonia

BMJ Case Rep. 2021 Jan 15;14(1):e240932. doi: 10.1136/bcr-2020-240932.

Abstract

A 53-year-old man with diabetes came to the emergency department with fever and dry cough for 5 days, swelling of the left leg for 2 days, shortness of breath and chest pain for 1 hour. He had raised temperature, tachycardia, tachypnoea, reduced oxygen saturation and swollen tender left leg on examination. The frontal chest radiograph showed bilateral ground-glass opacities; he tested positive for COVID-19 with elevated D-dimer. The colour Doppler examination of the left leg revealed acute deep vein thrombosis (DVT) of the common femoral and the popliteal veins. The chest CT showed bilateral diffuse ground-glass opacities predominantly involving peripheral zones and the lower lobes. The CTPA revealed left pulmonary thromboembolism (PTE), treated with low-molecular-weight heparin. COVID-19 predominantly affects the respiratory system. DVT and PTE are common in COVID-19 but lethal. They should be diagnosed early by clinical and radiological examinations and treated promptly with anticoagulants.

Keywords: COVID-19; radiology (diagnostics); venous thromboembolism.

Publication types

  • Case Reports

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives
  • Adenosine Monophosphate / therapeutic use
  • Alanine / analogs & derivatives
  • Alanine / therapeutic use
  • Anti-Bacterial Agents / therapeutic use
  • Anticoagulants / therapeutic use
  • Antiparasitic Agents / therapeutic use
  • Antiviral Agents / therapeutic use
  • COVID-19 / blood
  • COVID-19 / complications*
  • COVID-19 / diagnosis
  • COVID-19 / therapy
  • COVID-19 Drug Treatment
  • Computed Tomography Angiography
  • Diabetes Mellitus, Type 2 / complications
  • Doxycycline / therapeutic use
  • Femoral Vein
  • Fibrin Fibrinogen Degradation Products
  • Glucocorticoids / therapeutic use
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Humans
  • Ivermectin / therapeutic use
  • Male
  • Methylprednisolone / therapeutic use
  • Middle Aged
  • Oxygen Inhalation Therapy
  • Popliteal Vein
  • Pulmonary Embolism / diagnostic imaging
  • Pulmonary Embolism / etiology*
  • Pulmonary Embolism / therapy
  • SARS-CoV-2
  • Tomography, X-Ray Computed
  • Ultrasonography, Doppler, Color
  • Venous Thrombosis / diagnostic imaging
  • Venous Thrombosis / etiology*
  • Venous Thrombosis / therapy

Substances

  • Anti-Bacterial Agents
  • Anticoagulants
  • Antiparasitic Agents
  • Antiviral Agents
  • Fibrin Fibrinogen Degradation Products
  • Glucocorticoids
  • Heparin, Low-Molecular-Weight
  • fibrin fragment D
  • remdesivir
  • Adenosine Monophosphate
  • Ivermectin
  • Doxycycline
  • Alanine
  • Methylprednisolone