Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase

David Van Ly; Duo Wang; Robert Max Conway; Michael Giblin; Sharron Liang; Robyn Lukeis; Li-Anne Lim; Luke Hesson; Svetlana Cherepanoff

doi:10.1159/000510393

Lipid-Producing Ciliochoroidal Melanoma with Expression of HMG-CoA Reductase

Ocul Oncol Pathol. 2020 Dec;6(6):416-421. doi: 10.1159/000510393. Epub 2020 Oct 9.

Authors

David Van Ly^{1

2}, Duo Wang¹, Robert Max Conway^{3

4}, Michael Giblin⁴, Sharron Liang¹, Robyn Lukeis¹, Li-Anne Lim⁴, Luke Hesson^{5

6}, Svetlana Cherepanoff^{1

7}

Affiliations

¹ Anatomical Pathology, SydPath, St Vincent's Hospital, Sydney, New South Wales, Australia.
² School of Medicine, The University of Notre Dame Australia, Sydney, New South Wales, Australia.
³ Save Sight Institute, The University of Sydney, Sydney, New South Wales, Australia.
⁴ Sydney Eye Hospital, Sydney, New South Wales, Australia.
⁵ Kinghorn Centre for Clinical Genomics, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
⁶ Faculty of Medicine, Prince of Wales Clinical School, UNSW Sydney, Randwick, New South Wales, Australia.
⁷ Faculty of Medicine, St Vincent's Clinical School, UNSW, Darlinghurst, New South Wales, Australia.

Abstract

Uveal melanoma (UM) is the commonest primary intraocular malignancy in adults. There is limited published data on lipid production in UM. Here, we describe the clinical, histological, immunohistochemical, and molecular findings in a ciliochoroidal melanoma with lipid production and expression of the enzyme HMG-CoA reductase. This case highlights an unusual UM tumour phenotype with a high-risk molecular metastatic profile and discusses tumour lipogenesis and activation of the mevalonate pathway as a potential therapeutic target in managing lipidised ciliochoroidal UM.

Keywords: Cholesterol; HMG-CoA reductase; Lipids; Statin; Uveal melanoma.

Publication types

Case Reports