A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response

Mingming Xiao; Joshua S Fried; Jinlu Ma; Yang Su; Rebecca J Boohaker; Qinghua Zeng; Yaqi Mo; Fanbiao Meng; Rong Xiang; Bo Xu

doi:10.1038/s41392-020-00381-7

A disease-relevant mutation of SPOP highlights functional significance of ATM-mediated DNA damage response

Signal Transduct Target Ther. 2021 Jan 15;6(1):17. doi: 10.1038/s41392-020-00381-7.

Authors

Mingming Xiao^#¹, Joshua S Fried^#^{2

3}, Jinlu Ma^#^{2

3

4}, Yang Su¹, Rebecca J Boohaker^{2

3}, Qinghua Zeng^{2

3}, Yaqi Mo¹, Fanbiao Meng¹, Rong Xiang⁵, Bo Xu^{6

7

8

9}

Affiliations

¹ Department of Biochemistry and Molecular Biology, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China.
² Department of Oncology, Southern Research Institute, Birmingham, AL, 35205, USA.
³ Cell Biology Program, University of Alabama at Birmingham, Birmingham, AL, 35205, USA.
⁴ Department of Radiation Oncology, First Affiliated Hospital, Xian Jiaotong University, Xi'an, China.
⁵ Department of Biochemistry and Molecular Biology, Nankai University School of Medicine, Tianjin, China. rxiang@nankai.edu.cn.
⁶ Department of Biochemistry and Molecular Biology, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China. xubo@tmu.edu.cn.
⁷ Department of Oncology, Southern Research Institute, Birmingham, AL, 35205, USA. xubo@tmu.edu.cn.
⁸ Cell Biology Program, University of Alabama at Birmingham, Birmingham, AL, 35205, USA. xubo@tmu.edu.cn.
⁹ Center for Intelligent Oncology, Chongqing University Cancer Hospital, Chongqing University School of Medicine, Chongqing, 400030, China. xubo@tmu.edu.cn.

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Ataxia Telangiectasia Mutated Proteins* / genetics
Ataxia Telangiectasia Mutated Proteins* / immunology
DNA Damage* / genetics
DNA Damage* / immunology
DNA, Neoplasm* / genetics
DNA, Neoplasm* / immunology
Humans
Male
Neoplasm Proteins* / genetics
Neoplasm Proteins* / immunology
Nuclear Proteins* / genetics
Nuclear Proteins* / immunology
Prostatic Neoplasms / genetics
Prostatic Neoplasms / immunology*
Repressor Proteins* / genetics
Repressor Proteins* / immunology

Substances

DNA, Neoplasm
Neoplasm Proteins
Nuclear Proteins
Repressor Proteins
SPOP protein, human
ATM protein, human
Ataxia Telangiectasia Mutated Proteins