Functional crosstalk between Long non-coding RNAs and the NLRP3 inflammasome in the regulation of diseases

Mol Immunol. 2021 Mar:131:191-200. doi: 10.1016/j.molimm.2020.12.038. Epub 2021 Jan 11.

Abstract

Emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in various pathophysiological processes of disease, such as cancer occurrence, viral invasion, and inflammatory damage. The main inflammatory body component, nod-like receptor protein 3 (NLRP3), is the trigger point of inflammatory reactions and inflammation-related diseases and coordinates the body's response to inflammation. At present, increasing evidence shows that the interaction of lncRNAs and the NLRP3 inflammasome plays an important role in the inflammatory response and different diseases. This may be involved in the development and progression of various diseases by activating signalling pathways and a variety of molecular regulatory mechanisms-this article reviews progress in research on the relationship between lncRNAs and the NLRP3 inflammasome under different conditions.

Keywords: Inflammatory diseases; Inflammatory inflammasome; Long-chain non-coding RNA; NLRP3.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammasomes / genetics*
  • Inflammation / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein / genetics*
  • RNA, Long Noncoding / genetics*
  • Signal Transduction / genetics

Substances

  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • RNA, Long Noncoding