Biomolecular condensates in autophagy regulation

Yuko Fujioka; Nobuo N Noda

doi:10.1016/j.ceb.2020.12.011

Biomolecular condensates in autophagy regulation

Curr Opin Cell Biol. 2021 Apr:69:23-29. doi: 10.1016/j.ceb.2020.12.011. Epub 2021 Jan 11.

Authors

Yuko Fujioka¹, Nobuo N Noda²

Affiliations

¹ Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan.
² Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan. Electronic address: nn@bikaken.or.jp.

PMID: 33445149
DOI: 10.1016/j.ceb.2020.12.011

Abstract

Autophagy is an intracellular degradation system that contributes to cellular homeostasis. Autophagosome formation is a landmark event in autophagy, which sequesters and delivers cytoplasmic components to the lysosome for degradation. Based on selectivity, autophagy can be classified into bulk and selective autophagy, which are mechanistically distinct from each other, especially in the requirement of cargos for autophagosome formation. Recent studies revealed that liquid-like biomolecular condensates, which are formed through liquid-liquid phase separation, regulate the autophagosome formation of both bulk and selective autophagy. Here, we focus on recent findings on the involvement of biomolecular condensates in autophagy regulation and discuss their significance.

Keywords: Ape1; Autophagy; Biomolecular condensate; Bulk autophagy; Cvt pathway; PAS; Phase separation; Selective autophagy; p62.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autophagy*
Cytoplasm