Abstract
This report describes the development of a non-genetic cell-surface modification method, in which a self-assembling small molecule is combined with Halo-tag proteins. Cell-surface functionalization with cancer-linked extracellular proteins led to enhanced cell motility, angiogenesis, and immune shielding of the cells, paving the way for translational opportunities for cell therapy.
MeSH terms
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Angiopoietin-2 / chemistry
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Animals
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B7-H1 Antigen / chemistry
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Cell Line
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Cell Membrane
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Cell Movement
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Gene Expression Regulation
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Humans
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Matrix Metalloproteinase 2 / chemistry
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Mice
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Piperazines / chemistry*
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Vascular Endothelial Growth Factor A / chemistry
Substances
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Angiopoietin-2
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B7-H1 Antigen
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Piperazines
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Vascular Endothelial Growth Factor A
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adhesamine
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Matrix Metalloproteinase 2