Gluing Proteins for Targeted Degradation

Mikihiko Naito; Shigeo Murata

doi:10.1016/j.ccell.2020.12.020

Gluing Proteins for Targeted Degradation

Cancer Cell. 2021 Jan 11;39(1):19-21. doi: 10.1016/j.ccell.2020.12.020.

Authors

Mikihiko Naito¹, Shigeo Murata²

Affiliations

¹ Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan; National Institute of Health Sciences, Kawasaki, Kanagawa, Japan. Electronic address: mnaito@mol.f.u-tokyo.ac.jp.
² Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan. Electronic address: smurata@mol.f.u-tokyo.ac.jp.

PMID: 33434510
DOI: 10.1016/j.ccell.2020.12.020

Abstract

Targeted protein degradation is an emerging technology for drug development. An article published in Nature reported a novel mechanism of targeted protein degradation triggered by small-molecule-induced polymerization of the oncogenic transcription factor BCL6.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Adhesives*
Humans
Oncogenes*
Polymerization
Proteolysis
Proto-Oncogene Proteins c-bcl-6 / metabolism

Substances

Adhesives
BCL6 protein, human
Proto-Oncogene Proteins c-bcl-6