Lessons from the Study of Exceptional Responders

Arijh Elzein; Gopa Iyer; David B Solit

doi:10.1016/j.ccell.2020.11.008

Lessons from the Study of Exceptional Responders

Cancer Cell. 2021 Jan 11;39(1):11-13. doi: 10.1016/j.ccell.2020.11.008.

Authors

Arijh Elzein¹, Gopa Iyer², David B Solit³

Affiliations

¹ Department of Pharmacology, Weill Cornell Medicine Graduate School of Medical Sciences, New York City, NY, USA; Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
² Department of Medicine, Weill Cornell Medical College, New York City, NY, USA; Memorial Sloan Kettering Cancer Center, New York City, NY, USA.
³ Department of Cell and Developmental Biology, Weill Cornell Medicine Graduate School of Medical Sciences, New York City, NY, USA; Department of Medicine, Weill Cornell Medical College, New York City, NY, USA; Memorial Sloan Kettering Cancer Center, New York City, NY, USA. Electronic address: solitd@mskcc.org.

PMID: 33434508
DOI: 10.1016/j.ccell.2020.11.008

Abstract

In this issue of Cancer Cell, Wheeler et al. report that mechanisms of exceptional response to cancer treatment can be grouped into four broad categories: dysregulated intracellular signaling pathways, altered DNA damage response, tumor microenvironment or immune engagement, and alterations associated with a favorable prognosis.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Humans
Neoplasms* / drug therapy
Neoplasms* / genetics
Prognosis
Signal Transduction
Tumor Microenvironment