Abstract
The author describes his 60-year career in studying the chemistry of natural products, which includes structural, synthetic, and biosynthetic studies of natural products ranging from insect pigments, antibiotics, and fecal mutagens to taxol and other anticancer natural products as well as antimalarial natural products. One of the compounds discussed, napabucasin, is now an anticancer drug in phase III clinical trials.
Publication types
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Personal Narrative
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Antimalarials / chemistry
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Antineoplastic Agents / chemistry
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Biological Products / chemistry*
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Career Choice
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Drug Discovery*
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Paclitaxel / chemistry
Substances
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Anti-Bacterial Agents
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Antimalarials
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Antineoplastic Agents
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Biological Products
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Paclitaxel